What are the Sources of Cellular Heterogeneity in Cancer?
Cellular heterogeneity in cancer arises from several sources:
Genetic Mutations: Accumulation of mutations during cell division. Epigenetic Changes:Epigenetic modifications that affect gene expression without altering the DNA sequence. Microenvironmental Influences: The tumor microenvironment can induce phenotypic changes in cancer cells. Stem Cell Plasticity: Cancer stem cells can differentiate into various cell types, contributing to heterogeneity.
