What Are the Therapeutic Implications of ARID1A Mutations?
The identification of ARID1A mutations in cancer has significant therapeutic implications. Targeted therapies aimed at exploiting synthetic lethality, where the loss of ARID1A function is paired with the inhibition of other proteins or pathways essential for cancer cell survival, are being explored. For example, EZH2 inhibitors and ATR inhibitors are being investigated in preclinical and clinical studies for their potential effectiveness in ARID1A-mutated cancers.
