What Are the Therapeutic Implications of Targeting Cancer Metabolism?
Given the unique metabolic features of cancer cells, targeting metabolic pathways presents a promising therapeutic strategy. Inhibitors of glycolysis, glutaminolysis, and other metabolic pathways are being explored in preclinical and clinical studies. For example, metformin, a diabetes drug, has shown potential in inhibiting cancer cell growth by affecting mitochondrial metabolism. Moreover, targeting metabolic enzymes like IDH1/2 in certain cancers with specific mutations has demonstrated clinical efficacy.
