What are the Therapeutic Implications of Targeting the ALT Pathway?
Targeting the ALT pathway offers a promising avenue for cancer treatment, especially for tumors that do not rely on telomerase for telomere maintenance. Inhibitors of proteins involved in homologous recombination and DNA repair, such as ATR and BLM helicase, are being investigated for their potential to disrupt the ALT pathway. Additionally, understanding the unique vulnerabilities of ALT-positive cancer cells could lead to the development of combination therapies that enhance the efficacy of existing treatments.
