What are the Therapeutic Strategies Targeting CSCs?
Several therapeutic strategies are being explored to target CSCs, including:
1. Inhibitors of Key Signaling Pathways: Targeting pathways like Notch, Wnt, and Hedgehog can disrupt CSC maintenance and survival. 2. Differentiation Therapy: Inducing CSCs to differentiate into non-tumorigenic cells can reduce their ability to initiate and sustain tumors. 3. Immune-based Therapies: Enhancing the immune system's ability to recognize and eliminate CSCs through vaccines and adoptive cell transfer. 4. Combination Therapies: Using conventional treatments in combination with CSC-targeted therapies to achieve a more comprehensive eradication of cancer cells.
