Treatment of TLS focuses on both prevention and management of metabolic disturbances. Key strategies include:
Hydration: Aggressive intravenous hydration helps to maintain renal perfusion and facilitates the excretion of released cellular contents. Medications: Medications such as allopurinol or rasburicase can be used to reduce uric acid levels. Other agents may be required to manage potassium, phosphate, and calcium levels. Monitoring: Close monitoring of electrolytes, renal function, and cardiac status is essential for early detection and management of complications. Dialysis: In severe cases, renal replacement therapy such as dialysis may be necessary to manage refractory metabolic abnormalities and renal failure.
