There are several classes of DNA repair inhibitors, including:
- PARP Inhibitors: Drugs like olaparib and rucaparib inhibit PARP enzymes, leading to increased DNA damage and cell death in cancer cells. - ATR Inhibitors: Targeting the ATR kinase involved in the DNA damage response. - CHK1 Inhibitors: These inhibit the checkpoint kinase 1 (CHK1), which is crucial for cell cycle regulation in response to DNA damage. - ATM Inhibitors: Targeting the ATM kinase, which plays a role in signaling double-strand breaks.
