Atypia can result from various factors, including: - Chronic Inflammation: Persistent inflammatory conditions can lead to abnormal cell changes. - Infections: Some infections, such as those caused by the human papillomavirus (HPV), can induce atypia. - Environmental Exposures: Long-term exposure to harmful substances like tobacco smoke or radiation can lead to atypical cell development. - Genetic Mutations: Certain inherited genetic conditions can predispose individuals to cellular abnormalities.