Are There Any Emerging Strategies to Combat P-glycoprotein Mediated Resistance?
Emerging strategies include the development of more specific and less toxic P-gp inhibitors, as well as combination therapies that target multiple resistance mechanisms simultaneously. Nanoparticle-based drug delivery systems are also being explored to bypass P-gp mediated efflux. Additionally, gene editing technologies like CRISPR/Cas9 offer the potential to directly downregulate or knockout P-gp expression in cancer cells.
