Can P-glycoprotein Be Inhibited to Overcome Drug Resistance?
Yes, inhibiting P-gp is a promising strategy to overcome MDR in cancer therapy. Several P-gp inhibitors have been developed, including agents like verapamil, cyclosporine A, and tariquidar. These inhibitors can block the drug efflux function of P-gp, allowing higher intracellular concentrations of chemotherapeutic agents. However, the clinical success of these inhibitors has been limited due to issues like toxicity and lack of specificity.
