glycolytic enzymes

What Challenges Exist in Targeting Glycolytic Enzymes for Cancer Therapy?

Challenges include:
- Specificity: Ensuring that inhibitors selectively target cancer cells without affecting normal cells.
- Resistance mechanisms: Cancer cells may develop alternative metabolic pathways to circumvent inhibition.
- Toxicity: Potential side effects due to the essential role of glycolysis in normal cellular functions.

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