Which Glycolytic Enzymes are Commonly Upregulated in Cancer?
Several glycolytic enzymes are frequently upregulated in various cancers, including: - Hexokinase II (HK2): Initiates glycolysis by phosphorylating glucose, often found in high levels in cancer cells. - Phosphofructokinase-1 (PFK-1): A key regulatory enzyme controlling the rate of glycolysis. - Pyruvate Kinase M2 (PKM2): A variant that promotes anabolic growth and is associated with tumorigenesis.
