How Do Structural Variants Influence Cancer Treatment?
Understanding SVs in a patient's cancer can guide personalized treatment strategies. For example: 1. Targeted Therapies: Some drugs specifically target fusion proteins created by translocations, such as imatinib for BCR-ABL fusion in chronic myeloid leukemia. 2. Prognostic Markers: Certain SVs can indicate how aggressive the cancer is and guide treatment intensity. 3. Drug Resistance: SVs can lead to drug resistance, necessitating alternative treatment strategies.
