What Are the Challenges in Studying Structural Variants?
1. Complexity: SVs can be large and complex, making them difficult to detect and interpret. 2. Heterogeneity: Cancer is a heterogeneous disease, and SVs can vary widely between different tumors and even within the same tumor. 3. Technical Limitations: While technologies are improving, accurately detecting and characterizing SVs remains challenging, particularly for complex rearrangements.
