What Are Common Types of Structural Variants in Cancer?
1. Deletions: Loss of a DNA segment, which can remove essential genes involved in cell cycle regulation. 2. Duplications: Extra copies of a DNA segment, potentially leading to overexpression of oncogenes. 3. Inversions: Reversal of a DNA segment, which can disrupt gene function if it breaks a gene or regulatory element. 4. Insertions: Addition of extra DNA sequences, which can disrupt normal gene function. 5. Translocations: Rearrangement of parts between nonhomologous chromosomes, often creating fusion genes that drive cancer progression.
