Future research on E2F transcription factors in cancer is likely to focus on several key areas. These include understanding the specific roles of different E2F members in various cancer types, elucidating the mechanisms of E2F regulation and interaction with other pathways, and developing targeted therapies that can selectively modulate E2F activity. Advances in genomic and proteomic technologies will also aid in identifying novel E2F targets and biomarkers for cancer diagnosis and treatment.