Which Control Proteins are Most Frequently Altered in Cancer?
Several control proteins are frequently mutated or dysregulated in cancer. For instance, the tumor suppressor protein p53 is mutated in approximately 50% of all human cancers. The retinoblastoma protein (Rb) is another critical tumor suppressor often altered in cancer. Additionally, overexpression of cyclins and CDKs, particularly Cyclin D1 and CDK4/6, is common in various cancers, leading to unregulated cell cycle progression.
