E2F1 is one of the most studied members of the E2F family in the context of cancer. It is known to activate the transcription of a wide array of genes involved in DNA replication, cell cycle progression, and apoptosis. Overexpression of E2F1 has been observed in numerous cancers, including melanoma, lung cancer, and breast cancer. Interestingly, E2F1 also has a dual role as it can induce apoptosis under certain conditions, acting as a tumor suppressor. This dual role makes E2F1 a complex target for cancer therapy.
