How Do E2F Factors Interact with Other Oncogenic Pathways?
E2F transcription factors do not work in isolation; they interact with various other oncogenic pathways. For instance, the p53 pathway, another critical regulator of the cell cycle and apoptosis, is often intertwined with E2F activity. In many cancers, mutations in the p53 gene can lead to increased E2F activity, further promoting tumorigenesis. Additionally, E2Fs are regulated by cyclins and cyclin-dependent kinases (CDKs), which are also frequently dysregulated in cancer. These interactions underscore the complexity of E2F regulation and its implications in cancer.
