Despite its importance, annotation in cancer research faces several challenges:
Volume of Data: The sheer amount of data generated by modern sequencing technologies can be overwhelming. Data Integration: Combining data from different sources and formats is often complex. Functional Validation: Determining the biological significance of annotated features requires experimental validation, which can be time-consuming and costly. Updating Annotations: As new discoveries are made, existing annotations need to be updated to reflect the latest knowledge.
