What Challenges Exist in Genomic and Molecular Profiling?
Despite its potential, profiling faces several challenges:
Tumor Heterogeneity: Cancers can exhibit significant genetic diversity within the same tumor and between primary and metastatic sites, complicating the interpretation of profiling results. Data Interpretation: The vast amount of data generated by profiling requires sophisticated bioinformatics tools and expertise to accurately interpret and apply clinically. Accessibility: High costs and limited availability of profiling technologies can restrict access for many patients. Clinical Relevance: Not all detected alterations are clinically actionable, and their significance can be difficult to determine.
