What Challenges Exist in Targeting Met Amplification?
Despite the potential benefits of targeting MET amplification, several challenges remain. These include the development of resistance to MET inhibitors, either through additional mutations in the MET gene or activation of alternative signaling pathways. Furthermore, identifying patients who would benefit most from MET-targeted therapies requires reliable and precise diagnostic tools. The heterogeneity of MET amplification within tumors also poses a challenge for effective treatment.
