What Challenges Exist in Using Synthetic Lethality for Cancer Treatment?
Several challenges must be addressed to effectively use synthetic lethality in cancer treatment. One challenge is the genetic heterogeneity of tumors, which can lead to variable responses to synthetic lethal therapies. Additionally, identifying the right gene pairs and developing selective inhibitors can be complex and time-consuming. Lastly, resistance to synthetic lethal drugs can develop over time, necessitating combination therapies or new treatment strategies.
