Despite their compatibility, Cancer and Scorpio may face certain challenges. One potential issue is Scorpio's tendency to be possessive or jealous, which can make Cancer feel suffocated. Additionally, Cancer's moodiness might clash with Scorpio's intensity, leading to misunderstandings. To overcome these challenges, both partners need to work on maintaining mutual respect and giving each other space when needed. Effective communication and trust-building exercises can also help mitigate these issues.