How Do Serine Proteases Contribute to Cancer Progression?
Serine proteases contribute to cancer progression through multiple mechanisms. They can degrade the extracellular matrix (ECM), facilitating tumor invasion and metastasis. Additionally, they can activate other proteases and growth factors that promote tumor growth. Specific serine proteases, such as the urokinase-type plasminogen activator (uPA), have been implicated in the remodeling of the tumor microenvironment, further aiding cancer progression.
