How Can Serine Proteases Be Targeted for Cancer Treatment?
Targeting serine proteases for cancer treatment involves developing inhibitors that can specifically block their activity. Small molecule inhibitors, monoclonal antibodies, and peptide-based inhibitors are some approaches being explored. For instance, the inhibition of uPA with small molecules or antibodies has shown promise in preclinical studies for reducing tumor growth and metastasis. Additionally, targeting the signaling pathways activated by serine proteases is another therapeutic strategy.
