What Are the Challenges in Targeting Serine Proteases for Cancer Therapy?
One of the main challenges in targeting serine proteases for cancer therapy is their broad physiological roles. Inhibiting these enzymes can lead to unwanted side effects, such as impaired immune function or blood coagulation. Moreover, the redundancy and compensatory mechanisms within the protease network can reduce the efficacy of targeted therapies. Therefore, selective inhibition and a thorough understanding of the protease network are crucial for developing effective treatments.
