What Insights Can Pseudotime Analysis Provide in Cancer?
Pseudotime analysis can offer several valuable insights into cancer biology, including:
- Cell State Transitions: By mapping the progression of cell states, researchers can identify intermediate states that may contribute to malignancy. - Lineage Relationships: Understanding the developmental lineage of cancer cells can reveal how different subpopulations within a tumor arise and evolve. - Resistance Mechanisms: Tracking the pseudotime trajectory of cancer cells exposed to treatments can uncover mechanisms of drug resistance, aiding in the development of more effective therapies. - Tumor Microenvironment: Analysis of the tumor microenvironment along pseudotime can reveal interactions between cancer cells and their surrounding stromal and immune cells.
