Calcineurin is a calcium and calmodulin-dependent serine/threonine protein phosphatase involved in a myriad of cellular processes. It plays a crucial role in the activation of T-cells through the dephosphorylation and activation of the nuclear factor of activated T-cells (NFAT), which then translocates to the nucleus to initiate transcription of various genes. Calcineurin is composed of two subunits: a catalytic A subunit and a regulatory B subunit.
