Epigenetic profiling refers to the comprehensive analysis of epigenetic modifications on the DNA and histone proteins within a cell. These modifications, including DNA methylation, histone modifications, and non-coding RNA interactions, play crucial roles in regulating gene expression without altering the underlying DNA sequence. In the context of cancer, aberrant epigenetic changes can lead to the activation of oncogenes or the silencing of tumor suppressor genes, contributing to tumorigenesis and cancer progression.