Highly emetogenic chemotherapy (HEC) refers to chemotherapy treatments that have a high likelihood of causing nausea and vomiting. These side effects can significantly impact a patient's quality of life and their ability to continue with treatment. The emetogenic potential of a chemotherapy drug is determined by its tendency to cause these symptoms. Drugs are classified as highly emetogenic if they cause nausea and vomiting in more than 90% of patients without adequate antiemetic prophylaxis.