HOTAIR, or HOX Transcript Antisense Intergenic RNA, is a long non-coding RNA (lncRNA) that originates from the HOXC locus on chromosome 12. It is known for its role in epigenetic regulation, particularly in the modification of chromatin states and the regulation of gene expression. Unlike protein-coding RNAs, lncRNAs like HOTAIR do not translate into proteins but play crucial regulatory roles in various biological processes.