HOTAIR has been extensively studied for its role in cancer. Elevated levels of HOTAIR are often associated with various types of cancer, including breast cancer, colorectal cancer, and lung cancer. The overexpression of HOTAIR is linked to increased tumor invasiveness, metastasis, and poor prognosis. Through its interactions with polycomb repressive complex 2 (PRC2), HOTAIR can modify chromatin structure and silence tumor suppressor genes, thus promoting cancer progression.
