IRE1 (inositol requiring enzyme 1) is an endoplasmic reticulum (ER) membrane protein that plays a critical role in the unfolded protein response (UPR). The UPR is a cellular stress response related to the ER. IRE1 possesses dual enzymatic activity: kinase activity and endoribonuclease activity, both of which are essential for its function in maintaining protein homeostasis.
