NBS1, also known as Nibrin, is a protein encoded by the NBS1 gene. It plays a crucial role in the repair of DNA double-strand breaks, a type of DNA damage that can lead to cancer if not properly repaired. NBS1 is a part of the MRN complex, which includes MRE11 and RAD50, and is essential for maintaining genomic stability. This protein is involved in the detection and repair of DNA damage, signaling for cell cycle arrest, and initiating DNA damage repair processes.
