Are There Therapeutic Implications of Targeting NBS1?
Targeting NBS1 and the MRN complex could offer new avenues for cancer treatment, particularly in tumors that exhibit defects in DNA repair pathways. Inhibitors that disrupt the function of NBS1 could sensitize cancer cells to DNA-damaging agents, enhancing the efficacy of chemotherapy and radiotherapy. Moreover, synthetic lethality approaches could be employed to exploit the vulnerabilities in cancer cells with compromised DNA repair capabilities.
