What is Perineural Invasion and How Does it Affect Prognosis?
Perineural invasion (PNI) refers to the process by which cancer cells invade the spaces surrounding nerves. PNI is considered a marker of aggressive disease and is associated with a poor prognosis. It is commonly seen in cancers such as pancreatic, prostate, and head and neck cancers. The presence of PNI often indicates a higher likelihood of cancer recurrence and metastasis, necessitating more aggressive treatment approaches.
