Poly (ADP-Ribose) Polymerase (PARP) is a family of proteins involved in a number of cellular processes, including DNA repair, genomic stability, and programmed cell death. PARP enzymes, particularly PARP1, play a critical role in the repair of single-strand DNA breaks through the base excision repair pathway. When DNA damage occurs, PARP detects these breaks and facilitates their repair by poly-ADP-ribosylating various nuclear proteins, thus recruiting other proteins necessary for DNA repair.
