There are two primary methods of donation: bone marrow donation and peripheral blood stem cell (PBSC) donation. Bone marrow donation involves a surgical procedure under anesthesia, where marrow is extracted from the hip bone. PBSC donation, on the other hand, is a non-surgical procedure that involves taking blood from the donor, separating the stem cells, and returning the remaining blood to the donor. Both procedures are generally safe, though they may involve some discomfort and recovery time.