The future of PLGA in cancer therapy looks promising, with ongoing research focused on overcoming current challenges and enhancing the efficacy of PLGA-based treatments. Innovations in nanotechnology, drug formulation, and precision medicine are expected to drive the development of more effective and personalized PLGA-based cancer therapies. Moreover, the integration of PLGA with emerging technologies, such as immunotherapy and gene editing, holds potential for revolutionizing cancer treatment.