What is the Impact of Tumor Microenvironment on Degradation?
The tumor microenvironment plays a significant role in the degradation processes within cancer cells. Factors such as hypoxia, nutrient deprivation, and pH changes can influence the activity of degradation pathways. For example, hypoxia can lead to the stabilization of hypoxia-inducible factors (HIFs), which may alter the expression of genes involved in proteolysis and autophagy.
