What is the Link Between Fanconi Anemia and Cancer?
Individuals with Fanconi anemia have a significantly increased risk of developing cancers, particularly acute myeloid leukemia (AML) and squamous cell carcinomas of the head and neck. The compromised DNA repair capability in FA patients leads to genomic instability, which is a hallmark of cancer development. This pathway's dysfunction in non-FA individuals can also contribute to sporadic cancer cases, especially when other repair mechanisms fail.
