What is the Mechanism of Action of SCFAs in Cancer Cells?
SCFAs can induce cancer cell apoptosis by several mechanisms. Butyrate, for instance, inhibits HDAC, leading to the accumulation of acetylated histones and altered gene expression. This can activate pro-apoptotic genes and inhibit cell proliferation. SCFAs also modulate the immune system, enhancing the body's ability to target and destroy cancer cells.
