Autolytic debridement leverages the bodyâs inherent physiological processes to remove dead or necrotic tissue. The process involves the application of a moisture-retentive dressing that maintains a moist wound environment. This environment facilitates the activity of endogenous enzymes that break down necrotic tissue, thereby promoting natural tissue regeneration and healing. It is considered a selective form of debridement, meaning it targets only necrotic tissue without damaging healthy tissue.