Autolytic debridement is not suitable for all wound types. It should be avoided in wounds with active infection, heavy exudate, or when rapid removal of necrotic tissue is necessary. In cases where the patient has a compromised blood supply to the wound area, such as in peripheral vascular disease, autolytic debridement may not be effective. Additionally, it should not be used in combination with other debridement methods without careful planning and consultation with a healthcare professional.