What is the Prognostic Significance of IDH Mutations in Cancer?
The prognostic significance of IDH mutations varies by cancer type. In gliomas, IDH mutations are generally associated with a better prognosis and longer overall survival compared to wild-type IDH. In AML, the prognostic impact of IDH mutations is less clear, with studies showing mixed results. The presence of IDH mutations can influence treatment strategies and clinical outcomes.
