Isocitrate dehydrogenase (IDH) is an enzyme involved in the citric acid cycle, which is crucial for cellular energy production. The enzyme exists in three isoforms: IDH1, IDH2, and IDH3. IDH1 is found in the cytoplasm and peroxisomes, while IDH2 and IDH3 are located in the mitochondria. The primary function of IDH is to catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, producing NADPH in the process.
