What is the Role of DNA Mismatch Repair in Microsatellite Stability?
The DNA mismatch repair system includes several important proteins such as MLH1, MSH2, MSH6, and PMS2. These proteins work together to identify and correct mismatches that occur during DNA replication. When any of these MMR genes are mutated or epigenetically silenced, the repair system fails, leading to an accumulation of mutations and microsatellite instability.
