What is the Role of Mitotic Catastrophe in Cancer Treatments?
Many cancer therapies, including chemotherapeutic agents and radiation, aim to induce DNA damage or disrupt the mitotic spindle. These therapies rely on the activation of mitotic catastrophe to kill cancer cells. For instance, drugs like taxanes and vinca alkaloids interfere with microtubule dynamics, promoting mitotic errors that lead to cell death. Enhancing the efficiency of these treatments by targeting the pathways involved in mitotic catastrophe could improve therapeutic outcomes.
