The process of mitotic catastrophe can be triggered by various stressors, including DNA damage, incomplete DNA replication, or problems in the mitotic spindle assembly. These stressors activate cell cycle checkpoints, particularly the G2/M checkpoint, to prevent the propagation of damaged DNA. If the damage is irreparable, the cell may undergo mitotic catastrophe, characterized by chromosomal segregation defects and the formation of large, multinucleated cells.
